Nilay Shah
Consulting Senior Scientist | PhD in Biology and Molecular Epigenetics
Work Experience :
Consulting Senior Scientist, Neuberg Center for Genomic Medicine (2022-present) ? Adjust Assistant Professor, Sandip and Bhavini Research Institute (SBRI) (2023-present)
Postdoctoral Research Scientist, Stowers Institute for Medical Research,USA Research Project: To decipher DNA methylation patterns during co-binding of transcription factors at single-molecule level (2019-2023)
Research Scientist at Helmholtz Zentrum Munich, Germany Research Project: Role of RNA polymerase II in mediating transcription termination and gene regulation. (2017-2019)
Board of Studies Members, Xaviers College Ahmedabad (2023-present)
Board of Studies Members, Parul University, Baroda (2023-present)
Education:
PhD in Biology and Molecular Epigenetics Ludwig Maximilian University of Munich (LMU), Germany (2012-2017)
M.Sc. in Molecular Biotechnology University of Bonn, Germany (2010-2012)
B.Sc in Biochemistry with vocational Biotechnology St.Xaviers College, Gujarat University, India (2007-2010)
Publications
Horton, Connor A., Amr M. Alexandari, Michael G. B. Hayes, Emil Marklund, Julia M. Schaepe, Arjun K. Aditham, Nilay Shah, Avanti A. Shrikumar, Ariel Afek, and William J. Greenleaf. 2023. "Short tandem repeats bind transcription factors to tune eukaryotic gene expression." Science
Yahia, Yousra, Alexia Pigeot, Amal Zine El Aabidine, Nilay Shah, NezihKarasu, IgnasiForné, Stefan Krebs, Helmut Blum, Cyril Esnault, and Tom Sexton. 2023. "RNA polymerase II CTD is dispensable for transcription and required for termination in human cells." EMBO reports: e56150.
Alexandari, Amr M., Connor A. Horton, Avanti Shrikumar, Nilay Shah, Eileen Li, Melanie Weilert, Miles A. Pufall, Julia Zeitlinger, Polly M. Fordyce, and Anshul Kundaje. 2023. "De novo distillation of thermodynamic affinity from deep learning regulatory sequence models of in vivo protein-DNA binding." bioRxiv: 2023-05.
Nilay Shah, Tim-Michael Decker, and Dirk Eick. 2019. "Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells." Biology letters 15 (5): 20190068.
Nilay Shah, Muhammad Ahmad Maqbool, YousraYahia, Amal Zine El Aabidine, Cyril Esnault, Ignasi Forné, Tim-Michael Decker, David Martin, Roland Schüller, and Stefan Krebs. 2018. "Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals." Molecular cell 69 (1): 48-61.
Decker, Tim-Michael, IgnasiForné, Tobias Straub, HeshamElsaman, Guoli Ma, Nilay Shah, Axel Imhof, and Dirk Eick. 2019. "Analog-sensitive cell line identifies cellular substrates of CDK9." Oncotarget 10 (65): 6934.
Decker, Tim-Michael, Michael Kluge, Stefan Krebs, Nilay Shah, Helmut Blum, Caroline C. Friedel, and Dirk Eick. 2017. "Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1." Scientific reports 7 (1): 1684. ? Schüller, Roland, IgnasiForné, Tobias Straub, Amelie Schreieck, Yves Texier, Nilay Shah, Tim-Michael Decker, Patrick Cramer, Axel Imhof, and Dirk Eick. 2016. "Heptad-specific phosphorylation of RNA polymerase II CTD." Molecular cell 61 (2): 305-314.
Scientific Presentation
- Nutriepigenetics: The Future of Personalized Nutition, (Invited talk), 03/2025
- Beyond the genome: Tools, Techniques, and Trends in Epigenomics, (Invited talk), 08/2024
- Exploring the eclectic world of genomics, Parul University, (Invited talk), 12/2023
- All about RNA world, Science Club, NHL, (Invited talk), 08/2023
- ASBMB conference: Evolution and core processes in Gene expression (Poster presentation), 07/2022
- Young Investigator Science Retreat (YISR), Kansas City, USA, (Poster presentation), 09/2021
- Young Investigator Science Retreat (YISR), Kansas City, USA, (Poster presentation), 09/2019
- ASBMB Symposium: Transcription Regulation: Chromatin and RNA polymerase II, Snowbird, Utah, USA, (Poster presentation), 08/2018
- EMBO conference - Regulation of RNA 3’end formation across eukaryotic genomes, Oxford, UK (Poster Presentation), 09/2017
- 8th Munich Chromatin Day, Germany (Oral Presentation), 07/2017
- Abcam Conference - Chromatin and Epigenetics - from mechanism to function, Munich, Germany (Poster Presentation), 04/2017
- EMBL Conference - Transcription and Chromatin, Heidelberg, Germany (Poster Presentation), 08/2016
- CRC Conference - Chromatin Dynamics, Munich, Germany, (Poster Presentation), 03/2016
- 6th Munich Chromatin Day, Germany (Oral Presentation), 07/2015
- 11th EMBL Conference: Transcription and Chromatin, Heidelberg, Germany (Poster Presentation), 08/2014
Certifications and awards
- DBT- Research Associate fellowship, 2023 ? SERB – NPDF Fellowship, 2023
- Data analysis using R, ScienceCraft, Germany
- Project Management for Natural Sciences and Medical Research, LMU graduate center,Germany
- Good Manufacturing Practice(GMP), LSM graduate school, Germany
- Managing Conflict and Difficult situation, Helena graduate center, Germany
- S.J.Braganza research awards for Biological Science Research
